| Expression pattern: |
UP |
| Associated gene: |
SLC7A5, Ago2 |
| Associated microRNA: |
miR-199b-5p |
| Biological function: |
Promotes EC cell proliferation, leucine uptake, migration and invasion; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-199b-5p to regulate SLC7A5 expression (ceRNA-like axis), affecting leucine uptake and malignant behaviors. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot |
| Clinical significance: |
CircZNF124 expression was associated with EC severity and lymph node metastasis; proposed as a diagnostic biomarker and therapeutic target. |
| Description: |
CircZNF124 is up-regulated in endometrial cancer tissues and cell lines and is associated with higher FIGO stage and lymph node metastasis. Functionally, circZNF124 promotes proliferation, leucine uptake, migration/invasion, and xenograft tumor growth by sponging miR-199b-5p to de-repress SLC7A5. |
| Confidence score: |
0.7751 |