circRNA basic information
circBase ID: hsa_circ_0004913
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:62248459-62265775:-
Genomic location(hg38): chr17:64171099-64188415:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; non-tumor tissue; normal liver tissue
Cell lines:

MHCC97H; HCCLM3; MIHA; HCC97H
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TARDBP, INPPL1
Associated microRNA: miR-184
Biological function: Potential tumor-suppressive/anticarcinogenic role in HCC; may attenuate TARDBP-associated carcinogenesis.
Molecular mechanism: Binds TARDBP (RBP-circRNA complex); reported ceRNA-related regulation via miR-184/INPPL1.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits)
Detected method:
Q
M
Validation methods:

RT-qPCR; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; Microarray
Clinical significance:

-
Description:

hsa_circ_0004913 is down-regulated in HCC and experimentally binds the RBP TARDBP in HCC cells (RIP and RNA pull-down). The paper discusses that hsa_circ_0004913 may have an anticarcinogenic role and could potentially counteract TARDBP-driven HCC progression; it is also reported to be linked to a miR-184/INPPL1 regulatory relationship.
Confidence score:

0.5281
Other information
Title:

Identification of RNA binding protein interacting with circular RNA and hub candidate network for hepatocellular carcinoma.

Journal: Aging
Published: 2021
PubMed ID: 34133325
Study type:

combined biological and clinical study
Data availability: GSE78520; GSE97332; GSE94508; TCGA; ICGC; CPTAC; GSE14520
Code availability: -