| Expression pattern: |
UP |
| Associated gene: |
deltaNp63alpha, Ago2 |
| Associated microRNA: |
miR-21-5 p |
| Biological function: |
Acts as a ceRNA sponge for miR-21-5 p, decreases miR-21-5 p, increases deltaNp63alpha, and promotes EMT of endometrial epithelial cells leading to endometrial fibrosis. |
| Molecular mechanism: |
ceRNA mechanism: circPTPN12 sponges miR-21-5 p and counteracts miR-21-5 p-mediated repression of deltaNp63alpha, thereby inducing EEC-EMT. |
| Biological pathway or process: |
EMT (promotes); fibrosis (promotes); ceRNA regulation (promotes); migration (other); invasion (other) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; ISH (In Situ Hybridization); Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; FISH / smFISH; Transfection; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circPTPN12 (hsa_circ_0003764), derived from the PTPN12 gene, is up-regulated in fibrotic endometrium/IUA and mainly expressed in EECs. It localizes predominantly to the cytoplasm and acts as a ceRNA sponge for miR-21-5 p, lowering miR-21-5 p activity to de-repress deltaNp63alpha, thereby promoting EEC-EMT and endometrial fibrosis; miR-21-5 p supplementation counteracts these effects in vivo. |
| Confidence score: |
0.8558 |