| Expression pattern: |
UP |
| Associated gene: |
GRIK3 |
| Associated microRNA: |
miR-1205 |
| Biological function: |
Promotes colorectal cancer malignant progression by enhancing proliferation/colony formation, migration and invasion, and inhibiting G0/G1 arrest and apoptosis; supports tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for miR-1205 to induce GRIK3 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
CRC sufferers with high circASXL1 expression had poor prognosis compared with those with low circASXL1 expression. |
| Description: |
circASXL1 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation/colony formation, migration, invasion) while inhibiting G0/G1 arrest and apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-1205 to increase GRIK3 expression, and circASXL1 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7892 |