circRNA basic information
circBase ID: hsa_circ_0000011
Name: -
Synonym: Circ_0000011
Host Gene: hsa-miR-27a-3p
 
 
 
Disease basic information
DO ID:
 326
DO name: ischemia
Disease details: cerebral ischemia/reperfusion injury
Species: human
Species details: human
Sample type: cell line
Sample type details: HT-22 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NRIP1
Associated microRNA: hsa-miR-27a-3p
Biological function: Circ_0000011 level was increased in OGD/R-induced HT-22 cells. Silencing of circ_0000011 promoted cell proliferation and inhibited LDH release, apoptosis and inflammation in OGD/R-treated HT-22 cells.
Molecular mechanism: circ_0000011 was demonstrated to sponge miR-27a-3p, which directly targeted NRIP1. MiR-27a-3p inhibition or NRIP1 overexpression ameliorated the impacts of circ_0000011 silencing on cell proliferation, LDH release, apoptosis and inflammation in OGD/R-treated HT-22 cells.
Survival: -
Supported No.:
 1
Description:

Circ_0000011 promotes OGD/R-induced HT-22 cell impairments by elevating NRIP1 through sponging miR-27a-3p.
Other information
Title:

Circ_0000011 promotes cerebral ischemia/reperfusion injury via miR-27a-3p-dependent regulation of NRIP1.

Journal: Metab Brain Dis
Published: 2022/8/5
PubMed ID: 35925446