circRNA basic information
circBase ID: hsa_circ_0006404
Name: hsa_circ_FOXO3
Synonym: circFOXO3
Host Gene: FOXO3
Genomic location(hg19): chr6:108984657-108986092:+
Genomic location(hg38): chr6:108663454-108664889:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tumor tissues; tumor-side tissues; adjacent normal tissues
Cell lines:

FaDu; Cal27; UM1; UM2; SCC-4; SCC-9; SCC-15; SCC-25; HOK; HGF; HEK 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: KDM2A, Ago2
Associated microRNA: miR-214
Biological function: promotes OSCC cell invasion, proliferation, tumor growth and metastasis
Molecular mechanism: Acts as a miRNA sponge for miR-214, thereby up-regulating KDM2A expression
Biological pathway or process:

ceRNA regulation (promotes); invasion (promotes); migration (promotes); metastasis (promotes); proliferation (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Colony Formation Assay; CCK8; Western Blot; In Vivo Animal Model
Clinical significance:

The overexpression of circFOXO3 in OSCC provides new promising clinical biomarker for oral cancer diagnose.
Description:

circFOXO3 is up-regulated in OSCC tissues and cell lines and promotes invasion and proliferation. Mechanistically, it acts as a ceRNA by sponging miR-214, relieving repression of KDM2A and thereby promoting OSCC progression, with in vivo xenograft evidence.
Confidence score:

0.779
Other information
Title:

Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma.

Journal: Journal of cellular and molecular medicine
Published: 2022
PubMed ID: 34117688
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this article. Further details are available on request.
Code availability: -