| Expression pattern: |
UP |
| Associated gene: |
ABCC1 |
| Associated microRNA: |
miR-101 |
| Biological function: |
Exosomal circ_PIP5K1A promotes NSCLC cell proliferation, migration, invasion, tumor growth and cisplatin resistance, while inhibiting apoptosis; its knockdown suppresses NSCLC progression and enhances cisplatin sensitivity. |
| Molecular mechanism: |
circ_PIP5K1A acts as a ceRNA/miRNA sponge for miR-101 and positively regulates ABCC1 expression, thereby promoting NSCLC progression and reducing cisplatin sensitivity. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_PIP5K1A is upregulated in NSCLC tissues, serum samples and serum-derived exosomes, and exosomal circ_PIP5K1A may be a promising application in NSCLC diagnosis and treatment. |
| Description: |
circ_PIP5K1A is upregulated in NSCLC tissues, serum, cells and serum-derived exosomes. It promotes NSCLC progression and cisplatin resistance by sponging miR-101 and increasing ABCC1 expression, while its knockdown suppresses proliferation, migration, invasion and tumor growth and promotes apoptosis and cisplatin sensitivity. |
| Confidence score: |
0.78 |