| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
promotes cell proliferation, migration, invasion and EMT; inhibits apoptosis; promotes tumor growth and metastasis |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-361-3p to regulate SOX4 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circUBAP2 expression predicated poor outcome / poor survival in CC patients; prognostic marker for overall survival |
| Description: |
circUBAP2 is up-regulated in cervical cancer tissues/cell lines and its high expression is associated with poor overall survival. Functionally, circUBAP2 promotes proliferation, EMT, migration/invasion and metastasis while inhibiting apoptosis. Mechanistically, circUBAP2 acts as a ceRNA that sponges miR-361-3p to increase SOX4 expression (circUBAP2/miR-361-3p/SOX4 axis). |
| Confidence score: |
0.835 |