circRNA basic information
circBase ID: hsa_circ_0008797
Name: hsa_circ_GSK3beta
Synonym: circ_0008797
Host Gene: GSK3beta
Genomic location(hg19): chr3:119582265-119624699:-
Genomic location(hg38): chr3:119863418-119905852:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; matched adjacent normal tissues; tumor tissues; xenograft tumor tissues; lung tissues
Cell lines:

CALU3; CALU6; A549; H1229; H1299; HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: SOCS2, Ki-67, MMP2, HK2
Associated microRNA: miR-301a-3p
Biological function: Inhibits NSCLC cell proliferation, migration, invasion, aerobic glycolysis, tumor growth and metastasis, and enhances apoptosis.
Molecular mechanism: circ_0008797 acts as a miR-301a-3p sponge and facilitates SOCS2 expression, thereby suppressing malignant phenotypes and aerobic glycolysis in NSCLC.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); glycolysis (inhibits); apoptosis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Actinomycin D / DRB Stability Assay; RNase R Treatment; FISH / smFISH; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; TUNEL; IHC (Immunohistochemistry); Western Blot; In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Low circ_0008797 expression is associated with poor 60-month overall survival in NSCLC patients; circ_0008797 might be a promising target for NSCLC treatment.
Description:

circ_0008797 is down-regulated in NSCLC tissues and cell lines, and higher expression is associated with better overall survival. Functionally, circ_0008797 suppresses proliferation, migration, invasion, glycolysis, tumor growth and metastasis while promoting apoptosis. Mechanistically, it acts as a cytoplasmic miR-301a-3p sponge to increase SOCS2 expression.
Confidence score:

0.8712
Other information
Title:

circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2.

Journal: Environmental toxicology
Published: 2022
PubMed ID: 35305058
Study type:

combined biological and clinical study
Data availability: GSE158695
Code availability: -