circRNA basic information
circBase ID: hsa_circ_0059580
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr20:21306916-21338430:+
Genomic location(hg38): chr20:21326278-21357792:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCCLM3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with protrusions (CPs) versus cell bodies (CBs) in highly metastatic HCCLM3 cells; identified as differentially expressed candidate related to invasion/metastasis.
Molecular mechanism: Differential expression profiling; predicted circRNA/miRNA interaction network (computational prediction); no specific validated downstream mechanism reported for this circRNA.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0059580 is down-regulated in cell protrusions compared with cell bodies in highly metastatic HCCLM3 hepatocellular carcinoma cells, supported by RNA-seq and verified by PCR/RT-qPCR with concordant direction. It is treated as a candidate circRNA potentially linked to invasion/metastasis-associated protrusion biology, without a validated mechanistic axis in this study.
Confidence score:

0.1904
Other information
Title:

Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing.

Journal: Oncology letters
Published: 2021
PubMed ID: 34113396
Study type:

biological research
Data availability: available from the corresponding author upon reasonable request
Code availability: -