circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_16245-1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue samples; matched adjacent non-tumor tissues; liver tumors; paired noncancerous liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Shows increased expression in HCC tissues and favorable diagnostic sensitivity and specificity in the initial analysis.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic value in HCC based on ROC analysis, but hsa_circ_16245-1 was not detected in some HCC samples in the validation group.
Description:

hsa_circ_16245-1 was identified by circRNA microarray and validated by qRT-PCR as up-regulated in HCC tumor tissues in the initial patient set. ROC analysis suggested potential diagnostic value, although it was not pursued as the main prognostic marker because it was not detected in some HCC samples in the validation group.
Confidence score:

0.5047
Other information
Title:

Circular RNA Hsa_Circ_0091579 Serves as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Published: 2018
PubMed ID: 30453307
Study type:

combined biological and clinical study
Data availability: -
Code availability: -