| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa_miRNA_522-3p, hsa_miRNA_381-3p, hsa_miRNA_300, hsa_miRNA_15a-3p |
| Biological function: |
Potential diagnostic biomarker for gastric cancer (including early GC screening). |
| Molecular mechanism: |
Bioinformatics-predicted circRNA-miRNA interactions (putative miRNA sponge/ceRNA-like role), without experimental validation. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Significantly downregulated in GC tissue and gastric fluid and proposed as a biomarker for early GC screening; tissue levels correlate with tumor size, tumor stage, T stage, venous invasion, CEA and CA19-9. |
| Description: |
hsa_circ_000780 (host gene FAM107B) is significantly down-regulated in gastric cancer tissues and is also decreased in gastric fluid, supporting its potential as a noninvasive biomarker for early GC screening. Predicted miRNA partners include hsa_miRNA_522-3p, hsa_miRNA_381-3p, hsa_miRNA_300 and hsa_miRNA_15a-3p, but mechanistic interactions were not experimentally validated. |
| Confidence score: |
0.585 |