| Expression pattern: |
UP |
| Associated gene: |
CDS2, MAVS, SOGA1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration and invasion, and inhibits apoptosis of cSCC cells. |
| Molecular mechanism: |
Knockdown of exosomal circ-CYP24A1 decreases downstream targets CDS2, MAVS and SOGA1 in cSCC cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; TUNEL; Transwell Assay; Western Blot |
| Clinical significance: |
Circulating circ-CYP24A1 is up-regulated in cSCC and correlates with clinical features (maximum tumor diameter, tumor thickness, preoperative serum SCC-Ag and serum SCC-Ag 1 month after surgery), suggesting a potential non-invasive diagnostic biomarker. |
| Description: |
Exosomal circ-CYP24A1 is up-regulated in cSCC patient plasma. Silencing circ-CYP24A1 in exosomes suppresses malignant behaviors (reduced proliferation/migration/invasion and increased apoptosis) in cSCC cells and is associated with decreased CDS2, MAVS and SOGA1 expression. |
| Confidence score: |
0.7283 |