circRNA basic information
circBase ID: hsa_circ_0102231
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; NCI-H358; NCI-H1650; HCC827; NCI-H1299; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RBBP4
Associated microRNA: miR-145
Biological function: Promotes NSCLC cell proliferation and invasion
Molecular mechanism: hsa_circ_0102231 acts as a ceRNA sponge for miR-145 and up-regulates RBBP4 expression
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential target for NSCLC treatment; prognostic and therapeutic potential
Description:

hsa_circ_0102231 is up-regulated in NSCLC cell lines and mainly localized in the cytoplasm. It promotes NSCLC cell proliferation and invasion by sponging miR-145 and thereby increasing RBBP4 expression, suggesting potential therapeutic relevance.
Confidence score:

0.7296
Other information
Title:

Circular RNA hsa_circ_0102231 sponges miR-145 to promote non-small cell lung cancer cell proliferation by up-regulating the expression of RBBP4.

Journal: Journal of biochemistry
Published: 2021
PubMed ID: 33084863
Study type:

biological research
Data availability: The data are included within the manuscript.
Code availability: -