circRNA basic information
circBase ID: hsa_circ_0006220
Name: hsa_circ_TADA2A
Synonym: -
Host Gene: TADA2A
Genomic location(hg19): chr17:35800605-35800763:+
Genomic location(hg38): chr17:37440504-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TNBC tissues; BC tissues
Cell lines:

BT-549; MDA-MB-231; MDA-MB-468; SK-BR-3; T47D; MCF-7; MCF-10A; HEK 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CDH19
Associated microRNA: miR-197-5p
Biological function: inhibits proliferation, migration, and invasion of TNBC cells
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-197-5p to indirectly regulate CDH19 expression
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

It might be a potential diagnostic marker and therapeutic target for TNBC patients.
Description:

hsa_circ_0006220 is down-regulated in TNBC tissues and cell lines. It suppresses TNBC cell proliferation, migration, and invasion by acting as a ceRNA sponge for miR-197-5p, thereby increasing CDH19 expression.
Confidence score:

0.6521
Other information
Title:

CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer.

Journal: Annals of translational medicine
Published: 2021
PubMed ID: 34532373
Study type:

combined biological and clinical study
Data availability: https://dx.doi.org/10.21037/atm-21-2934
Code availability: -