| Expression pattern: |
UP |
| Associated gene: |
OIP5, CDC25A, CDCA4, CHEK1 |
| Associated microRNA: |
miR-103a-3p, miR-195-5p |
| Biological function: |
Promotes HCC cell viability and motility; exerts oncogenic effects via a miR-103a-3p/OIP5 ceRNA network. |
| Molecular mechanism: |
Acts as a ceRNA to regulate OIP5 through sponging miR-103a-3p; partial/limited validation for miR-195-5p target genes depending on cell line. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Transfection; CCK8; Wound Healing Assay |
| Clinical significance: |
- |
| Description: |
circ_0103672 is upregulated in HCC and supports proliferation/motility of HCC cells. It functions as a ceRNA regulating OIP5 via miR-103a-3p, with additional miR-195-5p-related target regulation only partially supported depending on cell line. |
| Confidence score: |
0.4469 |