| Expression pattern: |
UP |
| Associated gene: |
CHD4 / chromodomain helicase DNA-binding protein 4 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
circ_0006528 promotes cell proliferation, migration, invasion, ADM resistance, and ADM-resistant BCa tumor growth; circ_0006528 knockdown suppresses these malignant and chemoresistant phenotypes. |
| Molecular mechanism: |
circ_0006528 acts through a ceRNA-like mechanism by sponging miR-1236-3p to regulate CHD4 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Clinical Sample Validation; CCK8; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ_0006528 expression was associated with shorter overall survival in ADM-resistant BCa patients. |
| Description: |
circ_0006528 is up-regulated in ADM-resistant breast cancer tissues and cells and is associated with shorter overall survival. Functionally, circ_0006528 promotes proliferation, migration, invasion, ADM resistance, and tumor growth through the miR-1236-3p/CHD4 axis; its knockdown suppresses these phenotypes. |
| Confidence score: |
0.686 |