| Expression pattern: |
UP |
| Associated gene: |
RUNX2 |
| Associated microRNA: |
miR-635 |
| Biological function: |
Promotes NPC cell proliferation, invasion, and tumor growth. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-635 to increase RUNX2 expression, promoting NPC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); FISH / smFISH; Transfection; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
May serve as a potential therapeutic target for NPC. |
| Description: |
hsa_circ_0001554 (circRANBP17), derived from RANBP17, is up-regulated in nasopharyngeal carcinoma tissues and cell lines. It promotes NPC cell proliferation and invasion and enhances tumor growth by sponging miR-635 to increase RUNX2 expression (circRANBP17/miR-635/RUNX2 ceRNA axis). |
| Confidence score: |
0.8382 |