| Expression pattern: |
UP |
| Associated gene: |
IGF1R |
| Associated microRNA: |
miR-574-3p |
| Biological function: |
promotes proliferation, migration, invasion/metastasis, and radioresistance in colorectal cancer |
| Molecular mechanism: |
circ-MFN2 acts as a miRNA sponge for miR-574-3p, thereby positively regulating IGF1R expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
high circ-MFN2 expression was associated with advanced TNM stage, lymph node metastasis, tumor size, and lower overall survival rate of CRC patients |
| Description: |
circ-MFN2 is up-regulated in colorectal cancer tissues and cell lines and is associated with more advanced disease and worse overall survival. Functionally, circ-MFN2 promotes proliferation, migration/invasion (metastatic potential), and radioresistance by sponging miR-574-3p to increase IGF1R expression (circ-MFN2/miR-574-3p/IGF1R axis). |
| Confidence score: |
0.7657 |