| Expression pattern: |
UP |
| Associated gene: |
TRAF6, Ago2 |
| Associated microRNA: |
miR-1277 |
| Biological function: |
promotes IL-1beta-induced chondrocyte injury by inhibiting cell viability and facilitating apoptosis, inflammation and ECM degradation |
| Molecular mechanism: |
acts as a miRNA sponge for miR-1277 to positively regulate TRAF6 expression |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); inflammation (promotes); fibrosis (not specified) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot |
| Clinical significance: |
- |
| Description: |
circ-BRWD1 is upregulated in osteoarthritis cartilage and IL-1beta-stimulated chondrocytes and is enriched in the cytoplasm. It is transmitted via exosomes and aggravates IL-1beta-induced chondrocyte injury by sponging miR-1277 to increase TRAF6, thereby promoting apoptosis, inflammation and ECM degradation while reducing cell viability/proliferation. |
| Confidence score: |
0.7631 |