circRNA basic information
circBase ID: -
Name: hsa_circ_FNDC3B
Synonym: CircFNDC3B
Host Gene: FNDC3B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; adjacent normal tissues; plasma exosomes
Cell lines:

LoVo; SW480; SW620; HCT116; FHC; HUVEC; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: TIMP3, VEGFA, VEGFR
Associated microRNA: miR-937-5p
Biological function: Inhibits CRC cell proliferation, migration, invasion, EMT, angiogenesis, tumor growth and liver metastasis (tumor-suppressive).
Molecular mechanism: Acts as a miRNA sponge binding miR-937-5p, relieving repression of TIMP3; TIMP3 inhibits angiogenesis partly via VEGFA/VEGFR signaling, reducing VEGFR expression.
Biological pathway or process:

ceRNA regulation (promotes); angiogenesis (inhibits); migration (inhibits); invasion (inhibits); proliferation (inhibits); EMT (inhibits); metastasis (inhibits); VEGF/VEGFR (inhibits)
Detected method:
Q
Validation methods:

Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; ELISA; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model
Clinical significance:

-
Description:

circFNDC3B is down-regulated in colorectal cancer tissues/cell lines/exosomes and functions as a tumor suppressor. It sponges miR-937-5p to derepress TIMP3, thereby inhibiting EMT-associated proliferation, migration/invasion, angiogenesis (VEGFA/VEGFR), tumor growth and liver metastasis; circFNDC3B-enriched exosomes also convey anti-angiogenic effects.
Confidence score:

0.8279
Other information
Title:

CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression.

Journal: Molecular oncology
Published: 2020
PubMed ID: 32896063
Study type:

combined biological and clinical study
Data availability: exoRBase (http://www.exorbase.org/)
Code availability: -