| Expression pattern: |
DN |
| Associated gene: |
RND3, Ago2 |
| Associated microRNA: |
miR-574-5p |
| Biological function: |
inhibits cell proliferation/growth and promotes apoptosis; inhibits tumorigenesis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0008234 sponges miR-574-5p to upregulate RND3 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transfection; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Low expression of circ_0008234 predicted poor prognosis in LUAC patients; circ_0008234 expression was remarkably correlated with tumor size of LUAC patients |
| Description: |
hsa_circ_0008234 is down-regulated in LUAC and acts as a tumor suppressor by inhibiting proliferation and promoting apoptosis in vitro and in xenograft models. Mechanistically, it functions as a ceRNA that sponges miR-574-5p to increase RND3 expression, and higher circ_0008234 levels are associated with better patient prognosis. |
| Confidence score: |
0.8426 |