circRNA basic information
circBase ID: -
Name: hsa_circ_RNF13
Synonym: circRNF13
Host Gene: RNF13
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004844
MONDO name: oral mucosa leukoplakia
Disease details: oral leukoplakia
Disease DO ID:
 9655
Disease MeSH ID:
 D007972
Disease NCIt ID:
 C3187
Disease ICD11 ID:
 417308277
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OLK tissue; normal oral mucosal (NOM) tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-7-5p, miR-5683, miR-7107-3p, miR-4452, miR-580-5p
Biological function: -
Molecular mechanism: Predicted miRNA sponge interaction (bioinformatics prediction).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNF13 is up-regulated in OLK and validated by RT-qPCR. It is RNase R-resistant and was included in the constructed ceRNA network with predicted binding to miR-7-5p, miR-5683, miR-7107-3p, miR-4452, and miR-580-5p, but downstream effects were not experimentally tested.
Confidence score:

0.6193
Other information
Title:

Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.

Journal: Annals of translational medicine
Published: 2020
PubMed ID: 33313120
Study type:

combined biological and clinical study
Data availability: GSE131568
Code availability: -