| Expression pattern: |
UP |
| Associated gene: |
YAP1 |
| Associated microRNA: |
miR-665, miR-652-5p, miR-922, miR-466, miR-4739 |
| Biological function: |
Promotes gastric cancer cell proliferation, migration and invasion; suppresses apoptosis; promotes EMT. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) by binding miR-665 and thereby modulating YAP1 expression; regulates EMT-related protein expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
High circRNA_100876 expression is associated with poor prognosis (shorter disease-free survival) and correlates with aggressive clinicopathologic features (e.g., T stage, lymphatic metastasis/infiltration). |
| Description: |
circRNA_100876 is up-regulated in gastric cancer tissues/cells and its high expression is associated with worse patient survival. Functionally, circRNA_100876 promotes GC cell proliferation, migration, invasion and EMT while inhibiting apoptosis, mainly by sponging miR-665 to relieve repression of YAP1. |
| Confidence score: |
0.7126 |