circRNA basic information
circBase ID: -
Name: hsa_circ_SKI
Synonym: circSKIL
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011230
MONDO name: ossification of the posterior longitudinal ligament of the spine
Disease details: ossification of the posterior longitudinal ligament
Disease DO ID:
 0060887
Disease MeSH ID:
 C537143
Disease NCIt ID:
 C84975
Disease ICD11 ID:
 -
Disease OMIM ID:
 602475
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical posterior longitudinal ligament tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: JNK, STAT3
Associated microRNA: -
Biological function: Promotes proliferation, mineralization, and osteogenic differentiation of posterior longitudinal ligament cells in OPLL.
Molecular mechanism: Activates the JNK/STAT3 pathway (increased phosphorylation of JNK and STAT3).
Biological pathway or process:

JAK/STAT (promotes); MAPK (promotes); proliferation (promotes); osteogenic differentiation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Oil Red O Staining; Western Blot
Clinical significance:

-
Description:

circSKIL is up-regulated in OPLL posterior longitudinal ligament cells/tissues and promotes ligament-cell proliferation, mineralization, and osteogenic differentiation. Mechanistically, circSKIL activates the JNK/STAT3 signaling axis (increased JNK and STAT3 phosphorylation), while circSKIL knockdown suppresses these processes.
Confidence score:

0.5358
Other information
Title:

circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway.

Journal: Experimental and therapeutic medicine
Published: 2021
PubMed ID: 34035858
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -