| Expression pattern: |
UP |
| Associated gene: |
PFTK1 |
| Associated microRNA: |
miR-152-3p |
| Biological function: |
Promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth and lung metastasis in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-152-3p to upregulate PFTK1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; ISH (In Situ Hybridization); FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High hsa_circ_102229 level is correlated with poor prognosis and lower survival rate in TNBC patients; associated with lymph node metastasis, tumor size and TNM stage. |
| Description: |
hsa_circRNA_102229 (hsa_circ_102229) is up-regulated in TNBC and promotes proliferation, migration, invasion and metastasis while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-152-3p to increase PFTK1 expression, and high expression is associated with poor prognosis in TNBC patients. |
| Confidence score: |
0.8192 |