| Expression pattern: |
UP |
| Associated gene: |
AFF2, NM_001455 |
| Associated microRNA: |
hsa-miR-1-5p, hsa-miR-182-5p, hsa-miR-21-3p, hsa-miR-5006-5p |
| Biological function: |
Associated with immune imbalance and immune-related pathways in thymoma; may participate in immune disorders by affecting parental gene AFF2 (hypothesis). |
| Molecular mechanism: |
Predicted ceRNA mechanism via circRNA-miRNA-mRNA network; possible host-gene-related effect (hypothesis). |
| Biological pathway or process: |
MAPK (other); inflammation (other); immune regulation (other); apoptosis (other); PI3K/AKT (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Potential biomarker; parental gene AFF2 high expression associated with better overall survival in thymoma (circRNA itself not directly analyzed for survival). |
| Description: |
hsa_circ_0001947 is up-regulated in thymoma and is linked to immune-related signaling by circRNA-miRNA-mRNA network and KEGG analyses. The paper further suggests a possible relationship with its host gene AFF2 and reports parental-gene survival associations, but miRNA interactions were not experimentally validated. |
| Confidence score: |
0.6556 |