circRNA basic information
circBase ID: hsa_circ_0000301
Name: hsa_circ_SPL1
Synonym: -
Host Gene: SPL1
Genomic location(hg19): chr11:47379617-47379952:-
Genomic location(hg38): chr11:47358066-47358401:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; paired normal tissues; normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: CXCL16, IRF4, OAS3, PTGER3
Associated microRNA: hsa-miR-1178-3p, hsa-miR-1228-3p, hsa-miR-377-3p, hsa-miR-767-3p
Biological function: may be involved in the occurrence and development of cervical cancer
Molecular mechanism: construction of a circRNA-miRNA-mRNA network suggesting a ceRNA regulatory mechanism involving miR-1228-3p and IRF4
Biological pathway or process:

ceRNA regulation (other); Hippo/YAP (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

may provide novel biomarkers for the pathogenesis of cervical cancer
Description:

This study identified hsa_circ_0000301 as the sole core DE-circRNA from GSE102686 and constructed a circRNA-miRNA-mRNA network in cervical cancer. Bioinformatic predictions support a putative ceRNA axis involving hsa_circ_0000301, hsa-miR-1228-3p, and IRF4 (and additional axes with CXCL16, OAS3, PTGER3), suggesting involvement in cervical cancer development.
Confidence score:

0.1768
Other information
Title:

Hsa_circ_0000301 facilitates the progression of cervical cancer by targeting miR-1228-3p/IRF4 Axis.

Journal: BMC cancer
Published: 2021
PubMed ID: 34020619
Study type:

bioinformatics study
Data availability: GSE102686; 10.1186/s12885-021-08331-4
Code availability: -