| Expression pattern: |
UN |
| Associated gene: |
CXCR4 |
| Associated microRNA: |
miR-588 |
| Biological function: |
promotes proliferation and tumor growth, enhances migration/invasion, and inhibits apoptosis in LSCC cells |
| Molecular mechanism: |
circABCB10 acts as a miR-588 sponge, relieving miR-588-mediated repression of CXCR4 to promote malignant phenotypes in LSCC |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; Luciferase Reporter Assay; Western Blot; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circABCB10 promotes LSCC malignant behaviors (proliferation, migration/invasion and tumor growth) and inhibits apoptosis. Mechanistically, it sponges miR-588, thereby increasing CXCR4 expression; CXCR4 overexpression or miR-588 inhibition rescues the effects of circABCB10 knockdown. |
| Confidence score: |
0.5312 |