| Expression pattern: |
UP |
| Associated gene: |
KLF4, Ago2 |
| Associated microRNA: |
miR-3182 |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes chemo-resistance; enhances tumor growth in vivo |
| Molecular mechanism: |
Acts as a molecular sponge for miR-3182, thereby regulating KLF4 expression (circUBAP2/miR-3182/KLF4). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
circUBAP2 level was positively correlated with disease stage and metastatic status; potential biomarker for evaluation of lung cancer severity and metastasis prediction. |
| Description: |
circUBAP2 is up-regulated in NSCLC tumor tissues and NSCLC cell lines and is enriched in the cytoplasm. It promotes proliferation, migration/invasion, and chemoresistance, and accelerates xenograft tumor growth, largely via a ceRNA mechanism sponging miR-3182 to modulate KLF4. |
| Confidence score: |
0.8119 |