| Expression pattern: |
UP |
| Associated gene: |
ULK1 |
| Associated microRNA: |
miR-148a-3p |
| Biological function: |
Promotes CCA cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-148a-3p to positively regulate ULK1 expression (validated by dual-luciferase and rescue experiments). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_HIPK3 is up-regulated in cholangiocarcinoma and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, migration/invasion and tumor growth while promoting apoptosis and G0/G1 arrest, partly by sponging miR-148a-3p to upregulate ULK1. |
| Confidence score: |
0.6973 |