circRNA basic information
circBase ID: hsa_circ_0001681
Name: hsa_circ_RAPGEF5
Synonym: -
Host Gene: RAPGEF5
Genomic location(hg19): chr7:22330793-22357656:-
Genomic location(hg38): chr7:22291174-22318037:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: SARS-CoV-2 infection
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Calu-3; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: EIF4A3, FUS
Associated microRNA: -
Biological function: Potentially involved in antiviral transcriptional response during SARS-CoV-2 infection.
Molecular mechanism: Included in ceRNA network analysis; predicted to bind RBPs EIF4A3 and FUS.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other); inflammation (other); mRNA stability (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001681 (host gene RAPGEF5) is a dysregulated circRNA during SARS-CoV-2 infection validated by RT-qPCR and included in the ceRNA network analysis. It is predicted to interact with EIF4A3 and FUS, implying a potential role via RBP binding and RNA-level regulation during infection.
Confidence score:

0.2465
Other information
Title:

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Published: 2021
PubMed ID: 34004360
Study type:

combined biological and bioinformatics study
Data availability: PRJCA002617; https://doi.org/10.1016/j.meegid.2021.104923
Code availability: -