circRNA basic information
circBase ID: hsa_circ_0048764
Name: -
Synonym: circ_0048764
Host Gene: -
Genomic location(hg19): chr19:5690345-5691678:+
Genomic location(hg38): chr19:5690334-5691667:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues; tumor tissue
Cell lines:

MCF7; SKBR3; MDA-MB-231; MCF-10A; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM14, Ago2
Associated microRNA: miR-1296-5p
Biological function: promotes proliferation, migration and invasion; inhibits apoptosis
Molecular mechanism: circ_0048764 acts as a ceRNA sponging miR-1296-5p to upregulate TRIM14
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation)
Clinical significance:

circ_0048764 expression was associated with TNM stage and tumor size; potential prognostic biomarker
Description:

circ_0048764 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis by sponging miR-1296-5p to increase TRIM14 expression, forming a circ_0048764/miR-1296-5p/TRIM14 ceRNA axis.
Confidence score:

0.7415
Other information
Title:

Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.

Journal: Bioengineered
Published: 2022
PubMed ID: 34787066
Study type:

combined biological and clinical study
Data availability: GSE165884; The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -