| Expression pattern: |
UP |
| Associated gene: |
HMGA2 |
| Associated microRNA: |
miR-591 |
| Biological function: |
CircABCC1 promotes glioma cell proliferation, colony formation, migration, invasion, and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
CircABCC1 acts as a ceRNA by sponging miR-591, thereby upregulating HMGA2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
Inhibition of the circABCC1/miR-591/HMGA2 signaling axis might be a potential therapeutic target in glioma. |
| Description: |
CircABCC1 is up-regulated in human glioma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses glioma proliferation, colony formation, migration, invasion, and xenograft tumor growth while promoting apoptosis. Mechanistically, circABCC1 sponges miR-591 to relieve repression of HMGA2, forming a circABCC1/miR-591/HMGA2 ceRNA axis with potential therapeutic relevance. |
| Confidence score: |
0.7302 |