| Expression pattern: |
UP |
| Associated gene: |
PD-L1, Ago2 |
| Associated microRNA: |
miR-377-3p |
| Biological function: |
promotes tumorigenesis, proliferation, colony formation, migration and invasion in NSCLC |
| Molecular mechanism: |
ceRNA mechanism: circ_0000284 sponges miR-377-3p to up-regulate PD-L1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Survival Analysis |
| Clinical significance: |
High circ_0000284 expression is associated with low survival and may indicate NSCLC occurrence/progression |
| Description: |
circ_0000284 (circHIPK3) is up-regulated in NSCLC tissues/cell lines, mainly localized in the cytoplasm, and promotes NSCLC growth and metastatic behaviors. Mechanistically, it functions as a ceRNA to sponge miR-377-3p, thereby relieving repression of PD-L1 and enhancing PD-L1 expression; high circ_0000284 correlates with poorer patient survival. |
| Confidence score: |
0.8323 |