| Expression pattern: |
UP |
| Associated gene: |
FUS, ZNF609 pre-mRNA, GNB2, AGO2 |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
circZNF609 functions as an oncogenic circRNA in lung cancer, promoting LC cell proliferation, migration, and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
FUS binds the upstream region of ZNF609 pre-mRNA to promote circZNF609 formation and expression; circZNF609 acts as a miRNA sponge for miR-142-3p, relieving miR-142-3p-mediated repression of GNB2 and promoting LC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circZNF609 may be a new target of diagnosis and treatment for lung cancer. |
| Description: |
circZNF609 is up-regulated in lung cancer tissues and cell lines and acts as an oncogenic circRNA. FUS promotes circZNF609 biogenesis, and circZNF609 promotes proliferation, migration, and xenograft tumor growth while inhibiting apoptosis through the miR-142-3p/GNB2 axis. |
| Confidence score: |
0.8747 |