circRNA basic information
circBase ID: hsa_circ_0032821
Name: hsa_circ_CEP128
Synonym: -
Host Gene: CEP128
Genomic location(hg19): chr14:81209418-81227957:-
Genomic location(hg38): chr14:80743074-80761613:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal tissues; xenograft tumor tissues
Cell lines:

AGS; HGC-27; MKN74; MKN1; SNU-1; GES-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MEK1, ERK1/2
Associated microRNA: -
Biological function: Promotes cell proliferation, EMT, migration and invasion; inhibits autophagy; promotes tumor growth in vivo
Molecular mechanism: Activates MEK1/ERK1/2 signaling pathway
Biological pathway or process:

ERK (promotes); proliferation (promotes); EMT (promotes); migration (promotes); invasion (promotes); autophagy (inhibits)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Western Blot; Transwell Assay; In Vivo Animal Model
Clinical significance:

Associated with advanced TNM stage, lymphoid node metastasis and poor prognosis in gastric cancer
Description:

circ_0032821 is up-regulated in gastric cancer tissues and cell lines and correlates with advanced TNM stage, lymph node metastasis, and worse overall survival. Functionally, it promotes proliferation, EMT, migration/invasion and tumor growth while inhibiting autophagy, at least partly by activating the MEK1/ERK1/2 pathway.
Confidence score:

0.6516
Other information
Title:

Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32165864
Study type:

combined biological and clinical study
Data availability: GSE78092
Code availability: -