circRNA basic information
circBase ID: -
Name: hsa_circ_EBLN3
Synonym: hsa_circ_001783
Host Gene: EBLN3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

paraffin-embedded tissue samples; paired non-tumorigenesis tissue samples; fresh-frozen cancer specimens
Cell lines:

MCF-10A; T47D; BT474; SK-BR-3; MCF-7; MDA-MB-468; MDA-MB-231; HEK-293T; BT-549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ZEB1, ZEB2, ETS1, AGO2
Associated microRNA: miR-200c-3p
Biological function: promotes proliferation, migration, invasion and metastasis of breast cancer cells
Molecular mechanism: acts as a miRNA sponge for miR-200c-3p, leading to up-regulation of miR-200c-3p target genes (ZEB1, ZEB2, ETS1)
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

Bioinformatics Analysis; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Survival Analysis; Cohort Study; Clinical Sample Validation
Clinical significance:

Higher expression of hsa_circ_001783 associated with higher tumor burden and poorer prognosis; an independent factor for predicting prognosis (DFS).
Description:

hsa_circ_001783 is up-regulated in breast cancer (particularly TNBC) and mainly localized in the cytoplasm. It promotes proliferation and metastatic traits by sponging miR-200c-3p, thereby derepressing miR-200c-3p targets such as ZEB1/2 and ETS1. High hsa_circ_001783 expression correlates with heavier tumor burden and poorer disease-free survival, supporting its prognostic potential.
Confidence score:

0.8547
Other information
Title:

Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p.

Journal: Cell death & disease
Published: 2019
PubMed ID: 30670688
Study type:

combined biological and clinical study
Data availability: GSE40056; GSE28969; GSE41313; GSE28865; GSE43573; GSE21918; Supplementary Information accompanies this paper at (10.1038/s41419-018-1287-1).
Code availability: -