circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: circ_0001666
Host Gene: FAM120B
Genomic location(hg19): chr6:170626457-170639638:+
Genomic location(hg38): chr6:170317369-170330550:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

colorectal tumors; normal colorectal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: RASSF2
Associated microRNA: miR-1276
Biological function: potential tumor suppressive role in CRC
Molecular mechanism: ceRNA (miRNA sponge) mechanism: circ_0001666 sponges miR-1276 to affect RASSF2
Biological pathway or process:

ceRNA regulation (inhibits); proliferation (inhibits)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

suggested potential prognostic and therapeutic biomarker (not validated)
Description:

circ_0001666 is predicted to be down-regulated in CRC and may act as a tumor-suppressive circRNA. It is proposed (bioinformatically) to sponge miR-1276, potentially impacting the tumor suppressor gene RASSF2 via a ceRNA axis.
Confidence score:

0.1768
Other information
Title:

Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach.

Journal: Gastroenterology and hepatology from bed to bench
Published: 2021
PubMed ID: 33968341
Study type:

bioinformatics study
Data availability: GSE126095; GSE41657; GSE128435; GSE128449
Code availability: -