circRNA basic information
circBase ID: hsa_circ_0014879
Name: hsa_circ_DCAF8
Synonym: circ_0014879
Host Gene: DCAF8
Genomic location(hg19): chr1:160206924-160231148:-
Genomic location(hg38): chr1:160237134-160261358:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

colorectal tumors; normal colorectal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ARG2
Associated microRNA: miR-885-5p
Biological function: potential oncogenic (oncoCirc) role in CRC
Molecular mechanism: ceRNA (miRNA sponge) mechanism: circ_0014879 sponges miR-885-5p to upregulate ARG2
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); immune regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

suggested potential prognostic and therapeutic biomarker (not validated)
Description:

circ_0014879 is predicted to be up-regulated in CRC and may act as an oncogenic circRNA. Bioinformatics suggests a ceRNA axis where circ_0014879 sponges miR-885-5p, potentially increasing ARG2 expression and contributing to tumorigenesis/immune microenvironment effects.
Confidence score:

0.1768
Other information
Title:

Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach.

Journal: Gastroenterology and hepatology from bed to bench
Published: 2021
PubMed ID: 33968341
Study type:

bioinformatics study
Data availability: GSE126095; GSE41657; GSE128435; GSE128449
Code availability: -