| Expression pattern: |
UP |
| Associated gene: |
NRIP1 |
| Associated microRNA: |
miR-4298, miR-339-5p, miR-4687-3p, miR-548, miR-148p-5p, miR-3921, miR-7974, miR-1267, miR-1200, miR-4277 |
| Biological function: |
Acts as a diagnostic and dynamic monitoring biomarker for gastric cancer; may be released into blood by GC cells and potentially regulate GC progression. |
| Molecular mechanism: |
Predicted ceRNA (circRNA-miRNA-mRNA) regulatory network; mechanism not experimentally confirmed. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Plasma circ_0004771 distinguishes GC patients from healthy donors and gastritis patients (AUC=0.831 and 0.845), decreases to normal after surgery, and increases again in postoperative recurrence, supporting use as a diagnostic and dynamic monitoring biomarker. |
| Description: |
This study identifies plasma circ_0004771 (NRIP1-derived) as up-regulated in gastric cancer and demonstrates its value as a noninvasive diagnostic biomarker with good ROC performance. Its plasma level decreases after gastrectomy and increases again upon recurrence, supporting dynamic monitoring utility; a cytoplasmic ceRNA network with multiple predicted miRNAs is proposed but not experimentally validated. |
| Confidence score: |
0.6957 |