| Expression pattern: |
DN |
| Associated gene: |
PDCD4, Argonaute-2 (Ago2) |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
Circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion/aggressiveness and acts as a tumour-suppressor in gastric cancer. |
| Molecular mechanism: |
Circ_0026344 acts as a competing endogenous RNA by sponging miR-590-5p, thereby positively modulating PDCD4 expression and inhibiting gastric cancer progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ_0026344 expression was associated with larger tumour size, advanced TNM stage, lymph node metastasis and poor prognosis; circ_0026344 may be an indicator of the prognosis of patients with GC. |
| Description: |
hsa_circ_0026344/circ_0026344 is down-regulated in gastric cancer tissues and cell lines, and low expression is associated with aggressive clinicopathological features and shorter overall survival. Functionally, circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA for miR-590-5p and indirectly up-regulates PDCD4, forming a circ_0026344/miR-590-5p/PDCD4 tumor-suppressive axis. |
| Confidence score: |
0.8323 |