circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRA
Synonym: circPTPRA / circVPS16
Host Gene: PTPRA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005083
MONDO name: psoriasis
Disease details: psoriasis
Disease DO ID:
 8893
Disease MeSH ID:
 D011565
Disease NCIt ID:
 C3346
Disease ICD11 ID:
 63698555
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

skin biopsies; lesional skin; non-lesional skin
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Biomarker potential for disease severity and post-treatment disease resolution (correlates with PASI).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Others
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Correlates negatively with PASI and may have biomarker potential for disease severity and post-treatment disease resolution.
Description:

circPTPRA is downregulated in psoriatic lesional skin compared with non-lesional skin at baseline and progressively normalizes (increases) during secukinumab treatment. Its expression is strongly negatively correlated with PASI, suggesting biomarker potential for disease severity and treatment response.
Confidence score:

0.348
Other information
Title:

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.

Journal: PloS one
Published: 2022
PubMed ID: 36174034
Study type:

combined biological and clinical study
Data availability: S1 File; S2 File; S3 File; S4 File
Code availability: -