circRNA basic information
circBase ID: -
Name: hsa_circ_DNAH14
Synonym: chr1_224952669_224968874_+
Host Gene: DNAH14
Genomic location(hg19): chr1:225140371-225156576:+
Genomic location(hg38): chr1:224952669-224968874:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004992
MONDO name: cancer
Disease details: cancer
Disease DO ID:
 0050686, 0050687, 162
Disease MeSH ID:
 -
Disease NCIt ID:
 C9305
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

pan-cancer tissues; pan-normal tissues; plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DNAH14, chr1:224952669:G>A
Associated microRNA: -
Biological function: potential plasma cancer biomarker; associated with tumor microenvironment patterns
Molecular mechanism: cancer mutation near splice site potentially facilitates circRNA biogenesis; increasingly transcription-driven in cancer tissues
Biological pathway or process:

other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

significantly elevated in plasma exosomes from HCC and CRC patients as a potential plasma cancer biomarker
Description:

chr1_224952669_224968874_+ (DNAH14-derived) is pan-cancer tissue-enriched and is elevated in multiple cancer tissues and in plasma exosomes from HCC and CRC patients, suggesting biomarker potential. Its increased expression in cancer appears increasingly transcription-driven and may be facilitated by a nearby splice acceptor mutation (chr1:224952669:G>A).
Confidence score:

0.1768
Other information
Title:

Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 34604037
Study type:

bioinformatics study
Data availability: CSCD; exoRbase (Sequence Read Archive raw RNA sequencing data); MiOncoCirc; Supplementary Material
Code availability: GitHub repository ()