circRNA basic information
circBase ID: -
Name: hsa_circ_SMAD2
Synonym: circSMAD2
Host Gene: SMAD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCC827; NCI-H1944; NCI-H1993; NCI-H2347
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: increases colony formation; associated with fast proliferation
Molecular mechanism: not specified
Biological pathway or process:

proliferation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay
Clinical significance:

-
Description:

circSMAD2 is upregulated in fast-proliferating NSCLC cell lines and enhances colony formation upon overexpression, indicating a pro-growth role in vitro.
Confidence score:

0.6166
Other information
Title:

The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.

Journal: Cancers
Published: 2020
PubMed ID: 32353949
Study type:

biological research
Data availability: Supplementary Table S2; Supplementary Table S3; Supplementary Table S4; Supplementary Table S5; Supplementary Figure S2
Code availability: -