| Expression pattern: |
UP |
| Associated gene: |
mRNAs (candidate ceRNAs) |
| Associated microRNA: |
hsa-miR-30b-5p, hsa-miR-30c-5p, hsa-miR-518a-5p, hsa-miR-326, hsa-miR-199b-5p, hsa-miR-22-3p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-661, hsa-miR-23b-5p, hsa-miR-133b, hsa-miR-133a-3p, hsa-miR-330-5p |
| Biological function: |
Potential involvement in the progression/pathogenesis of Crohn's disease; potential diagnostic biomarker. |
| Molecular mechanism: |
Predicted ceRNA network (circRNA/miRNA/mRNA) via microRNA response elements (MREs); functional prediction by GO/KEGG enrichment of target mRNAs. |
| Biological pathway or process: |
ceRNA regulation (other); IL-17 signaling (other); Toll-like receptor signaling (other); TNF signaling (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Favorable diagnostic value for Crohn's disease (AUC = 0.858). |
| Description: |
hsa_circ_0001666 is up-regulated in colon tissues from Crohn's disease patients versus UC and healthy controls, and shows diagnostic potential (AUC 0.858). Bioinformatics predicts it may act in a circRNA/miRNA/mRNA (ceRNA) network and be linked to inflammatory/immune pathways relevant to CD. |
| Confidence score: |
0.6556 |