circRNA basic information
circBase ID: hsa_circ_0040824
Name: hsa_circ_BANP
Synonym: circ-BANP
Host Gene: hsa-miR-370
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TXNIP
Associated microRNA: hsa-miR-370
Biological function: The inhibition of circ-BANP promoted cell viability, migration, invasion, tube formation, and repressed cell inflammation and apoptosis in ox-LDL-induced HUVECs, demonstrating that circ-BANP silencing alleviated ox-LDL-induced HUVEC injury.
Molecular mechanism: circ-BANP directly targeted miR-370.TXNIP was a target of miR-370, and miR-370 overexpression relieved ox-LDL-induced HUVEC injury by downregulating TXNIP.
Survival: -
Supported No.:
 1
Description:

Our findings demonstrated that circ-BANP regulated ox-LDL-induced cell injury in HUVECs at least in part through targeting the miR-370/TXNIP axis, illuminating circ-BANP as a potential target for AS detection and treatment.
Other information
Title:

Circular RNA Circ-BANP Regulates Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury Through Targeting the miR-370/Thioredoxin-interacting Protein Axis.

Journal: J Cardiovasc Pharmacol
Published: 2020/12/11
PubMed ID: 33298736