| Expression pattern: |
UP |
| Associated gene: |
HAS2, Ago2, FAK, Akt |
| Associated microRNA: |
miR-488-3p, miR-625-5p, miR-1197 |
| Biological function: |
promotes EMT, migration, invasion and lung metastasis |
| Molecular mechanism: |
ceRNA mechanism: circ_102002 sponges miR-488-3p to upregulate HAS2, promoting FAK/Akt phosphorylation and EMT-associated changes |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes); PI3K/AKT (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High hsa_circ_102002 expression was associated with a relatively lower survival rate and higher probability of lymph node metastasis and distant metastases in PTC patients. |
| Description: |
Hsa_circRNA_102002 (circ_102002; hsa_circ_102002) is up-regulated in papillary thyroid cancer and promotes EMT, migration/invasion and in vivo lung metastasis. Mechanistically, it sponges miR-488-3p to relieve repression of HAS2, leading to increased FAK/Akt phosphorylation and EMT marker changes; high expression is associated with poorer overall survival and metastasis. |
| Confidence score: |
0.8456 |