circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circ-PVT1
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BEAS-2B; HCC827; H1299; PC-9; A549; A549/DDP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FOXK1
Associated microRNA: miR-429
Biological function: promotes proliferation, migration and invasion; promotes cisplatin (DDP) resistance and reduces DDP-induced apoptosis
Molecular mechanism: ceRNA mechanism: circ-PVT1 sponges miR-429 to relieve miR-429-mediated suppression of FOXK1, promoting malignant phenotypes and cisplatin resistance
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

-
Description:

circ-PVT1 is upregulated in lung adenocarcinoma cell lines and in cisplatin-resistant A549/DDP cells. Functionally, circ-PVT1 promotes proliferation, migration and invasion, and increases cisplatin resistance by inhibiting DDP-induced apoptosis. Mechanistically, circ-PVT1 acts as a ceRNA to sponge miR-429, thereby upregulating FOXK1 and driving the circ-PVT1/miR-429/FOXK1 axis.
Confidence score:

0.5301
Other information
Title:

Knockdown of circ‑PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR‑429/FOXK1 signaling axis.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 34328193
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -