| Expression pattern: |
UP |
| Associated gene: |
WEE1 |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
promotes HCC cell proliferation and migration/invasion; inhibits apoptosis; promotes tumorigenesis |
| Molecular mechanism: |
Acts as a miR-532-3p sponge to regulate WEE1 expression (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; EdU Staining; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ0013958 was positively correlated with poor prognosis of HCC patients; may serve as a potential diagnostic biomarker and therapeutic target of HCC. |
| Description: |
circ0013958 is up-regulated in hepatocellular carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, and tumor growth) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-532-3p to increase WEE1 expression, and higher circ0013958 is associated with poor patient prognosis. |
| Confidence score: |
0.7552 |