| Expression pattern: |
UP |
| Associated gene: |
RAB15 |
| Associated microRNA: |
miR-1182 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth and metastasis in vivo |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1182, thereby regulating RAB15 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; In Vivo Animal Model; Western Blot; Clinical Sample Validation; Cohort Study; Microarray |
| Clinical significance: |
circCSPP1 expression was correlated with histological grade and tumor size; potential biomarker/diagnostic and therapeutic target |
| Description: |
circCSPP1 is up-regulated in liver cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion, tumor growth/metastasis) by sponging miR-1182 and relieving miR-1182-mediated repression of RAB15 (ceRNA mechanism). |
| Confidence score: |
0.8635 |