| Expression pattern: |
UP |
| Associated gene: |
WNT5A, AGO2 |
| Associated microRNA: |
miR-545, miR-1270 |
| Biological function: |
promotes proliferation, migration and invasion of BCa cells; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circZFR sponges miR-545 and miR-1270 to upregulate WNT5A and activate Wnt/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
circZFR expression is positively correlated with prognosis; higher circZFR abundances are associated with lower survival rates in BCa patients |
| Description: |
circZFR is up-regulated in bladder cancer tissues and cell lines and promotes BCa proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, circZFR sponges miR-545 and miR-1270 to derepress WNT5A and activate Wnt/beta-catenin signaling, and high circZFR is associated with poorer patient survival. |
| Confidence score: |
0.8252 |