circRNA basic information
circBase ID: -
Name: hsa_circ_KCNN2
Synonym: circKCNN2
Host Gene: KCNN2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer disease
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

parietal cortex tissue; inferior frontal gyrus tissue (Brodmann area 44); frontal pole (BM10); superior temporal gyrus (BM22); parahippocampal gyrus (BM36)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Significantly associated with AD traits (CDR, Braak score, and AD case status) with decreased expression as dementia severity increases.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Clinical Sample Validation
Clinical significance:

Associated with AD clinical dementia severity (CDR), neuropathological severity (Braak), and AD case status in meta-analysis.
Description:

circKCNN2 is consistently down-regulated with increasing AD severity and is significantly associated with CDR, Braak score, and AD case status across multiple cortical region meta-analyses. No specific mechanism was experimentally validated in this study.
Confidence score:

0.4773
Other information
Title:

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.

Journal: Nature neuroscience
Published: 2019
PubMed ID: 31591557
Study type:

combined biological and clinical study
Data availability: NG00083; syn3159438; syn3157743
Code availability: Supplementary Software