circRNA basic information
circBase ID: hsa_circ_0001627
Name: hsa_circ_BACH2
Synonym: circ_BACH2
Host Gene: BACH2
Genomic location(hg19): chr6:90959407-90981660:-
Genomic location(hg38): chr6:90249688-90271941:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; adjacent normal tissues; xenograft tumor tissues
Cell lines:

TPC-1; SW579; Nthy-ori3-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: GIT1, Snail, Twist1, E-cadherin
Associated microRNA: miR-370-3p
Biological function: circ_BACH2 promotes PTC cell proliferation, colony formation, migration, invasion, cell-cycle progression and tumor growth, and inhibits apoptosis.
Molecular mechanism: circ_BACH2 negatively regulates miR-370-3p and thereby regulates GIT1 expression, affecting PTC progression and EMT-related proteins.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); EMT (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

circ_BACH2 is up-regulated in papillary thyroid cancer tissues and cell lines. Functionally, circ_BACH2 promotes malignant biological behaviors of PTC cells, including proliferation, migration, invasion, EMT-related changes and tumor growth, while suppressing apoptosis. Mechanistically, circ_BACH2 acts through the miR-370-3p/GIT1 regulatory axis.
Confidence score:

0.7183
Other information
Title:

[circ_BACH2 affects the malignant biological behavior of papillary thyroid cancer by regulating miR-370-3p].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology]
Published: 2024
PubMed ID: 39034802
Study type:

combined biological and clinical study
Data availability: -
Code availability: -