| Expression pattern: |
UP |
| Associated gene: |
PLCB1 |
| Associated microRNA: |
miR-1225-5p |
| Biological function: |
Circ_0091579 promotes HCC cell proliferation, clonogenicity, migration, invasion, metastasis and in vivo tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0091579 acts as a miR-1225-5p sponge and positively regulates PLCB1 expression, thereby promoting HCC progression and tumorigenesis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Circ_0091579 is upregulated in HCC tissues and cells and functions as a tumor-promoting circRNA. Its knockdown suppresses HCC cell proliferation, clonogenicity, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0091579 sponges miR-1225-5p to increase PLCB1 expression. |
| Confidence score: |
0.6542 |